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References Category:Film series introduced in 2008 Category:Film series Category:Young adult novel series Category:Young adult fictionLaura Pezzini Laura Pezzini (born 5 September 1993) is an Italian female middle-distance runner. She won the silver medal at the 2017 European Athletics Indoor Championships in the women's 1500 metres. She represented her country at the 2019 World Athletics Championships in Doha, Qatar and won the bronze medal in the women's 1500 metres. International competitions 1Disqualified in the final Personal bests Outdoor 800 metres – 2:00.40 ( Milano 2014) 1000 metres – 2:41.42 ( Belgrade 2019) 1500 metres – 4:02.00 ( Saint-Étienne 2019) Indoor 800 metres – 2:05.89 ( Tbilisi 2019) 1000 metres – 2:41.99 ( Marseille 2019) 1500 metres – 4:03.25 ( Marseille 2019) References External links Category:1993 births Category:Living people Category:Italian female middle-distance runners Category:World Athletics Championships athletes for Italy Category:People from Vercelli Category:Athletes of Gruppo Sportivo Esercito Category:European Games competitors for Italy Category:Athletes (track and field) at the 2019 European GamesPROJECT SUMMARY/ABSTRACT This application seeks to train a postdoctoral fellow in a career in drug development for the treatment of insomnia. Insomnia affects approximately 25% of adults. We have developed novel compounds with potent, selective, and orally active GPR50 agonists that modulate sleep. GPR50 is a 7-transmembrane G protein-coupled receptor expressed in multiple brain regions associated with sleep/wake behavior. We propose that GPR50 agonists provide a unique opportunity to modulate sleep via a novel mechanism of action without the need to rely on positive allosteric modulators of the GABA-B receptor. Our preliminary data indicates that GPR50 agonists bind the receptor with nanomolar affinity and have dose-dependent effects on sleep. Importantly, GPR50 agonists cause less sedation and brain excitation than positive allosteric modulators of the GABA-B receptor. We have developed a series of highly potent and selective non-peptide compounds based on our unique structure-activity relationship ( be359ba680


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